Pleiotrophin human
SIGMA/P5333 - ≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture
Synonym: HARP; HB-GAM; Heparin affinity regulatory peptide; Heparin-binding growth factor; Heparin-binding growth-associated molecule; PTN
MDL Number: MFCD01324256
Product Type: Chemical
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| assay | ≥97% (SDS-PAGE) |
| biological source | human |
| form | lyophilized powder |
| impurities | endotoxin, tested |
| mol wt | predicted mol wt 15.3 kDa |
| packaging | pkg of 50 μg |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf21 cells |
| storage condition | avoid repeated freeze/thaw cycles |
| storage temp. | −20°C |
| technique(s) | cell culture | mammalian: suitable |
| UniProt accession no. | P21246  |
| Analysis Note: | The activity is measured in culture by the ability to enhance neurite outgrowth of cerebral cortical neurons from rat embryos. |
| Application: | PTN is active in growth and development, and has mitogenic and neurite outgrowth activity. The gene for pleiotrophin is highly expressed in brain, uterus, gut, muscle, lung, and skin tissues |
| Biochem/physiol Actions: | Pleiotrophin may be the first member of a family of developmentally regulated cytokines. It is active in growth and development and the pleiotrophin gene is highly expressed in brain, uterus, gut, muscle, lung, and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, fibroblasts, astrocytes, Schwann cells, and tumor cells. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin. |
| Biochem/physiol Actions: | Pleiotrophin participates in growth and development. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin. |
| General description: | Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). This gene is highly expressed in brain, uterus, gut, muscle, lung and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, tumor cells, fibroblasts, astrocytes and Schwann cells. |
| Physical form: | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |