Phosphomycin disodium salt

SIGMA/P5396 - antibacterial MurA inhibitor

Synonym: (−)-(1R,2S)-(1,2-Epoxypropyl)phosphonic acid; Fosfomycin; Phosphonomycin

Empirical Formula (Hill Notation): C₃H₅Na₂O₄P
Molecular Weight: 182.02
EC Number: 247-409-2
MDL Number: MFCD22741288
Linear Formula: C₃H₅Na₂O₄P
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P5396-1G	1 g	$49.20 1/EA		Add To Favorites
45-P5396-5G	5 g	$146.00 1/EA		Add To Favorites
45-P5396-50G	50 g	$876.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
form	powder
InChI	1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
InChI key	QZIQJIKUVJMTDG-JSTPYPERSA-L
mode of action	cell wall synthesis \| interferes
Quality Level	200
SMILES string	[Na+].[Na+].C[C@@H]1O[C@@H]1P([O-])([O-])=O
storage temp.	2-8°C

Application:	Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections. It is used for susceptibility studies of Klebsiella pneumoniae and to study in vitro susceptibility testing procedures for fosfomycin tromethamine.
Biochem/physiol Actions:	Antibiotic that concentrates in kidney and bladder; reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. Fosfomycin is a phosphoenolpyruvate analog that irreversibly inhibits UDP-GlcNAc enolpyruvyl tranferase (MurA), an enzyme involved in bacterial cell wall biosynthesis. As a result, the production of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall, is inhibited.
Other Notes:	1g,5g,50g
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	51102829

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