PD-118057

SIGMA/P5624 - ≥98% (HPLC), solid

Synonym: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

CAS Number: 313674-97-4
Empirical Formula (Hill Notation): C₂₁H₁₇Cl₂NO₂
Molecular Weight: 386.27
MDL Number: MFCD08705328
Linear Formula: C₂₁H₁₇Cl₂NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P5624-5MG	5 mg	$243.00 1/EA		Add To Favorites
45-P5624-25MG	25 mg	$637.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	light yellow
form	solid
InChI	1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
InChI key	ZCQOSCDABPVAFB-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2
solubility	DMSO: 9 mg/mL
storage temp.	−20°C

Biochem/physiol Actions:	Activator of ether-a-go-go-related (hERG) potassium channel. Used in the treatment of congestive heart failure.
Biochem/physiol Actions:	PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335 - H413
Precautionary statements	P273 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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