Putrescine dihydrochloride
SIGMA/P5780 - powder, BioReagent, suitable for cell culture
Synonym: 1,4-Butanediamine dihydrochloride; 1,4-Diaminobutane dihydrochloride; Tetramethylenediamine dihydrochloride
CAS Number: 333-93-7
Empirical Formula (Hill Notation): C4H12N2 · 2HCl
Molecular Weight: 161.07
EC Number: 206-375-9
MDL Number: MFCD00012526
Linear Formula: NH2(CH2)4NH2 · 2HCl
Product Type: Chemical
| assay | ≥97% (TLC) |
| biological source | microbial |
| synthetic | |
| form | powder |
| InChI | 1S/C4H12N2.2ClH/c5-3-1-2- |
| InChI key | XXWCODXIQWIHQN-UHFFFAOYSA |
| mp | 280 °C (dec.) (lit.) |
| product line | BioReagent |
| Quality Level | 200  |
| SMILES string | Cl[H].Cl[H].NCCCCN |
| solubility | H2O: 100 mg/mL |
| technique(s) | cell culture | mammalian: suitable |
| Application: | Putrescine dihydrochloride has been used as medium component in F-12 + GlutaMax medium for mice ganglia culture, retinal ganglion cell culture and in HCT116 colon carcinoma cells for ornithine decarboxylase (ODC) assay. |
| Biochem/physiol Actions: | Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine. |
| Biochem/physiol Actions: | Binds to the polyamine modulatory site of the NMDA receptor; potentiates NMDA-induced currents. |
| Biochem/physiol Actions: | Putrescine is regarded as a marker of stress in plants. External supplementation of putrescine helps wheat plants to overcome drought stress. It is crucial for cell proliferation in animals and modulates abscisic acid (ABA) levels during cold stress in Arabidopsis plants. It serves as an attractant for predators. |
| General description: | Putrescine is an end product of fatty acid metabolism in dead tissues. It is a volatile diamine with pungent odour. It is synthesized by the decarboxylation of ornithine in the presence of enzyme, ornithine decarboxylase. Molecular docking studies reveal the binding of putrescine to human receptors called the trace amine-associated receptors (TAAR6 and TAAR8), present in olfactory epithelium. |
| Symbol |   GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H302 - H311 - H314 - H330 |
| Precautionary statements | P260 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | ≥97% (TLC) |
| mp | 280 °C (dec.) (lit.) |
| UNSPSC | 12352207 |