Anti-Potassium Channel Kir2.1 antibody produced in rabbit
SIGMA/P6102 - affinity isolated antibody, lyophilized powder
Synonym: Anti-ATFB9; Anti-HHBIRK1; Anti-HHIRK1; Anti-IRK1; Anti-KIR2.1; Anti-LQT7; Anti-SQT3
MDL Number: MFCD02686542
Product Type: Chemical
Immunoblotting Anti-Kir2.1: Cat. No. P6102: Western blot analysis of Rat heart (lanes 1,3) and Rat brain (lanes 2,4) membranes. Lanes 1,2. Anti-Kir2.1 antibody, (1:200). 3,4. Anti-Kir2.1, antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| western blot (chemiluminescent): 1:200 | |
| UniProt accession no. | Q64273  |
| Biochem/physiol Actions: | Potassium voltage-gated channel subfamily J member 2 (KCNJ2) has been shown to have a role in the differentiation and proliferation of bone marrow-derived macrophages (BMDM) in mice. It allows the inward movement of K+ into the cell and maintains its balance. Mutations in the KCNJ2 gene have been linked to Andersen-Tawil syndrome. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Potassium voltage-gated channel subfamily J member 2 (KCNJ2) is an inward-rectifying potassium channel. This tetrameric protein possesses two transmembrane helix domains (M1 and M2), an ion-selective P-loop between M1 and M2 and cytoplasmic amino and carboxy-terminal domains. The gene encoding KCNJ2 is localized on human chromosome 17q24.3. |
| Immunogen: | synthetic peptide corresponding to amino acids 392-410 of human Kir2.1 (with additional N-terminal cysteine). This epitope is identical in rabbit, bovine, pig, and guinea pig and highly homologous in rat, mouse and chicken. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.025% sodium azide. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H312 + H332 - H412 |
| Precautionary statements | P261 - P271 - P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Codes | T |
| Risk Statements | 24/25-52/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |