5-(4-Phenoxybutoxy)psoralen

SIGMA/P6124 - ≥98% (HPLC), solid

Synonym: PAP-1

CAS Number: 870653-45-5
Empirical Formula (Hill Notation): C₂₁H₁₈O₅
Molecular Weight: 350.36
MDL Number: MFCD11114059
Linear Formula: C₂₁H₁₈O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P6124-5MG	5 mg	$272.00 1/EA		Add To Favorites
45-P6124-25MG	25 mg	$1070.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white
form	solid
InChI	1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
InChI key	KINMYBBFQRSVLL-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C1Oc2cc3occc3c(OCCCCOc4ccccc4)c2C=C1
solubility	DMSO: 9 mg/mL
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	5-(4-Phenoxybutoxy)psoralen (PAP-1) is derived from 5-methoxypsoralen, a natural compound. PAP-1 show higher selectivity for Kv1.3 (voltage-gated potassium channels) than other Kv1 family members. Kv1.3 is predominant on cell membranes of activated effector memory T-cells. Inhibition of Kv1.3 results in membrane depolarization. In rat models, PAP-1 is known to delay the onset of diabetes. It might be used in the treatment of psoriasis and effector memory T cells mediated autoimmune diseases. Oral, intraperitoneal and topical administration of PAP-1 prevents allergic contact dermatitis induced by oxazolone.
Biochem/physiol Actions:	Selective inhibitor of K_v1.3, voltage-gated K⁺ channel.
Biochem/physiol Actions:	Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC₅₀=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.
Features and Benefits:	This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	5, 25 mg in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H334
Precautionary statements	P261 - P342 + P311
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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