Prostaglandin I₂ sodium salt

SIGMA/P6188 - ≥96% (HPLC), synthetic, powder

Synonym: (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt; Epoprostenol sodium salt; PGI₂-Na; Prostacyclin sodium salt

CAS Number: 61849-14-7
Empirical Formula (Hill Notation): C₂₀H₃₁NaO₅
Molecular Weight: 374.45
EC Number: 263-273-7
Linear Formula: C₂₀H₃₁NaO₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P6188-1MG	1 mg	$495.00 1/EA	Add To Favorites
45-P6188-5MG	5 mg	$2060.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P6188-10MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥96% (HPLC)
biological source	synthetic
color	white to off-white
form	powder
functional group	carboxylic acid
	hydroxyl
InChI	1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
InChI key	OURCVRVJQMLUNA-QFDVFERUSA-M
Quality Level	200
shipped in	ambient
SMILES string	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=CCCCC(O)=O.[Na]
solubility	ethanol: 50 mg/mL
	H₂O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.)
storage temp.	−20°C

Application:	Prostaglandin I2 sodium salt has been used: • in the preparation of stock solution for platelet washing procedure • as supplement in platelet-rich-plasma, for platelet preparation • to prevent platelet activation
Biochem/physiol Actions:	Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A₂ and stimulating platelet adenylyl cyclase. Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.
Biochem/physiol Actions:	Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.
Packaging:	1, 5, 10 mg in glass bottle

Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	22-26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥96% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352401

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