p53 human
SIGMA/P6249 - recombinant, expressed in E. coli, buffered aqueous glycerol solution
Product Type: Chemical
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| application(s) | genomic analysis |
| assay | ≥90% (SDS-PAGE) |
| biological source | human |
| form | buffered aqueous glycerol solution |
| Quality Level | 200  |
| recombinant | expressed in E. coli |
| shipped in | wet ice |
| storage temp. | −20°C |
| UniProt accession no. | P04637  |
| Application: | Useful for the study of postranslational modification of p53, or protein-protein interaction studies. |
| Biochem/physiol Actions: | p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer. |
| General description: | GST-tagged, full-length human p53 |
| General description: | p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |