Protein Phosphatase 2A1 bovine
SIGMA/P6993 - ≥1500 units/mg protein
Synonym: PPA2A1
MDL Number: MFCD00241719
Product Type: Chemical
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| assay | ≥90% (SDS-PAGE) |
| biological source | bovine |
| form | solution |
| mol wt | 192 kDa |
| packaging | vial of 1 μg |
| Quality Level | 200  |
| shipped in | dry ice |
| specific activity | ≥1500 units/mg protein |
| storage temp. | −70°C |
| Application: | Protein phosphatase 2A1 has been used to treat human fibroblast cells prior to western blot analysis. |
| Biochem/physiol Actions: | Protein Phosphatase 2A is a cytoplasmic protein, which colocalizes with microtubule proteins and is involved in the dephosphorylation of the tau protein and oncoprotein 18. Protein Phosphatase 2A1 (PP2A1) binds to polymerized microtubule proteins and may be targeted by tubulin in modulating phosphatase activity. PP2A1 is implicated as a growth suppressor and is associated with dysregulation in cancer. It also regulates cell cycle, RNA splicing differentiation, and signal transduction. PP2A dysfunction is correlated to the tau protein deregulation in Alzheimer′s disease pathophysiology. Protein Phosphatase 2A1 is a divalent cation-dependent protein serine/threonine phosphatase implicated as a growth suppressor and is associated with dysregulation in cancer. |
| General description: | Protein Phosphatase 2A1 (PP2A1) belongs to the PP2A family and comprises trimeric A, B and C subunits. PPA2 enzymes are serine/threonine phosphatases and exist as several isoforms. |
| Other Notes: | One unit will release 1.0 nanomole of phosphate from 32P-labeled phosphorylase A per minute at pH 7.0 at 30 °C. |
| Physical form: | Solution in 50 mM Tris-HCl, pH 7.0, containing 14 mM 2-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (SDS-PAGE) |
| activity | specific activity: ≥1500 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352204 |