Pyrazinecarboxamide

SIGMA/P7136

Synonym: Pyrazinamide; Pyrazinoic acid amide

CAS Number: 98-96-4
Empirical Formula (Hill Notation): C₅H₅N₃O
Molecular Weight: 123.11
EC Number: 202-717-6
MDL Number: MFCD00006132
Linear Formula: C₅H₅N₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P7136-10G	10 g	$82.10 1/EA	Add To Favorites
45-P7136-25G	25 g	$117.00 1/EA	Add To Favorites
45-P7136-100G	100 g	$398.00 1/EA	Add To Favorites

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This image depicts SKU: P7136-100G

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	mycobacteria
form	powder
InChI	1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
InChI key	IPEHBUMCGVEMRF-UHFFFAOYSA-N
mode of action	cell membrane \| interferes
mp	189-191 °C (lit.)
Quality Level	200
SMILES string	NC(=O)c1cnccn1

Application:	Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention and mechanisms of resistance .
Biochem/physiol Actions:	The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide . Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	10, 25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	189-191 °C (lit.)
UNSPSC	41116107

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