Plumbagin from Plumbago indica
SIGMA/P7262
Synonym: 5-
CAS Number: 481-42-5
Empirical Formula (Hill Notation): C11H8O3
Molecular Weight: 188.18
EC Number: 207-569-6
MDL Number: MFCD00001682
Linear Formula: C11H8O3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P7262-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P7262-1G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P7262-250MG
| biological source | Plumbago indica |
| color | faint orange to dark orange |
| form | powder |
| InChI | 1S/C11H8O3/c1-6-5-9(13)10 |
| InChI key | VCMMXZQDRFWYSE-UHFFFAOYSA |
| mp | 76-78 °C (lit.) |
| Quality Level | 200  |
| SMILES string | CC1=CC(C2=C(C1=O)C=CC=C2O |
| storage temp. | −20°C |
| Application: | Plumbagin from Plumbago indica has been used: • as a reactive oxygen species agent (ROS) to induce cytotoxicity in mouse embryonic fibroblasts • as an oxidative stress inducer to generate superoxide anion in Saccharomyces cerevisiae • as a reference standard in thin layer chromatography and in spectrophotometric analysis for quantification of plumbagin in Plumbago auriculate samples |
| Biochem/physiol Actions: | Exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action. |
| Biochem/physiol Actions: | Plumbagin exhibits various pharmacological activities including antimicrobial, anticancer, anti-atherosclerotic, antidiabetic, anti-inflammatory, hypolipidemic, and neuroprotective activities. It inhibits the signal transducer and activator of transcription 3 (STAT3) signaling and halts the proliferation of esophageal squamous cell carcinoma (ESCC). Plumbagin elicits protective antioxidative functionality in 4-nitroquinoline-N-oxide (NQNO) induced stress in lymphoma. Plumbagin in a nanoemulsion formulation has antiproliferative effect towards prostate cancer. |
| General description: | Plumbagin is a bioactive naphthoquinone present majorly in Plumbago indica L. It is a quinoid and is also derived from the roots of Plumbago zeylanica roots. |
| Packaging: | 1 g in glass bottle |
| Packaging: | 100, 250 mg in glass bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H315 - H319 - H335 |
| Precautionary statements | P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 25-34 |
| Safety Statements | 22-26-36/37/39-45 |
| RIDADR | UN 2923 6.1(8) / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 76-78 °C (lit.) |
| Storage Temp. | −20°C |
| UNSPSC | 12352205 |