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L-trans-Pyrrolidine-2,4-dicarboxylic acid

SIGMA/P7575 - ≥98%

Synonym: (2S,4R)-Pyrrolidine-2,4-Dicarboxylic Acid; L-trans-2,4-PDC; trans-4-Carboxy-L-proline

CAS Number: 64769-66-0
Empirical Formula (Hill Notation): C6H9NO4
Molecular Weight: 159.14
MDL Number: MFCD00153866
Linear Formula: C6H9NO4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P7575-2MG 2 mg
 $80.20
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45-P7575-10MG 10 mg
 $257.00
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assay ≥98%
form powder
InChI 1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1
InChI key NRSBQSJHFYZIPH-DMTCNVIQSA-N
Quality Level 100 
SMILES string OC(=O)[C@H]1CN[C@@H](C1)C(O)=O
Application: L-trans-Pyrrolidine-2,4-dicarboxylic acid has been used:
• as a glutamate transport inhibitor to test its impairing effect on glutamate-induced cell death in HT22 neuronal cells
• as an analog of glutamate to test its effect on glutamate/glutamine-dependent acid resistance of E. coli and S. flexneri
• as sodium glutamate (Na+/Glu) cotransporter inhibitor in myogenic cell line C2C12
Biochem/physiol Actions: L-trans-Pyrrolidine-2,4-dicarboxylic acid is a selective glutamate transporter inhibitor.
Packaging: 2, 10 mg in glass insert
Purity ≥98%
UNSPSC 12352106

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