Prazosin hydrochloride
SIGMA/P7791 - ≥99.0% (HPLC)
Synonym: 1-
CAS Number: 19237-84-4
Empirical Formula (Hill Notation): C19H21N5O4 · HCl
Molecular Weight: 419.86
EC Number: 242-903-4
MDL Number: MFCD00058177
Linear Formula: C19H21N5O4 · HCl
Product Type: Chemical
| assay | ≥99.0% (HPLC) |
| form | powder |
| InChI | 1S/C19H21N5O4.ClH/c1-26-1 |
| InChI key | WFXFYZULCQKPIP-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cl.COc1cc2nc(nc(N)c2cc1OC |
| solubility | dilute aqueous acid: insoluble |
| H2O: 0.5 mg/mL | |
| methanol: 6 mg/mL |
| Application: | Prazosin hydrochloride has been used: • to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice • as an α1-adrenoceptor blocker,administered intragastrically in rats • as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions |
| Biochem/physiol Actions: | Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure. |
| Disclaimer: | Hygroscopic; light sensitive. |
| Features and Benefits: | This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the α1-Adrenoceptors , α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| General description: | Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H336 - H361fd - H373 |
| Precautionary statements | P201 - P202 - P260 - P271 - P280 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-62 |
| Safety Statements | 28-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (HPLC) |
| UNSPSC | 12352200 |