Phloretin

SIGMA/P7912 - ≥99%

Synonym: β-(4-Hydroxyphenyl)-2,4,6-trihydroxypropiophenone; 2′,4′,6′-Trihydroxy-3-(4-hydroxyphenyl)propiophenone; 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone

CAS Number: 60-82-2
Empirical Formula (Hill Notation): C₁₅H₁₄O₅
Molecular Weight: 274.27
EC Number: 200-488-7
MDL Number: MFCD00002288
Linear Formula: C₁₅H₁₄O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P7912-25MG	25 mg	$75.00 1/EA	Add To Favorites
45-P7912-100MG	100 mg	$149.00 1/EA	Add To Favorites
45-P7912-250MG	250 mg	$292.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P7912-100MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99%
form	powder
InChI	1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
InChI key	VGEREEWJJVICBM-UHFFFAOYSA-N
mp	~260 °C
Quality Level	200
SMILES string	Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
storage temp.	2-8°C

Application:	Phloretin has been used: • to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-l-glucose (2-NBDLG) uptake • to incubate microvesicles in order to inhibit GLUT1 (glucose transporter 1)-mediated transport in radioactive ligand up-take assay • as a component of KRH buffer to stop glucose uptake by trophoblast cells in vitro
Biochem/physiol Actions:	Blocks L-type Ca²⁺ channels; activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers. Monocarboxylate transporter inhibitor.
Biochem/physiol Actions:	Phloretin is known to decrease interfacial dipole potential of lipid bilayer. Phloretin possess antitumor action by preventing protein kinase C (PKC) activity and stimulating programmed cell death. It is found to inhibit the transport functions of GLUTs (glucose transporter) and aquaporins.
Biochem/physiol Actions:	Reacts with vic-dicarbonyl compounds such as glyoxal and methylglyoxal, preventing cytotoxic conjugation with biological macromolecules.
General description:	Major polyphenol found in apple; aglycone of phloridzin.
General description:	Phloretin a polar dye belongs to the class of dihydrochalcones.
Packaging:	25, 100, 250 mg in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99%
mp	~260 °C
Storage Temp.	2-8°C
UNSPSC	12352202

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