4α-Phorbol 12,13-didecanoate

SIGMA/P8014 - solid

Synonym: 4α-Phorbol 12-13-dicaprinate; 4αPDD

CAS Number: 27536-56-7
Empirical Formula (Hill Notation): C₄₀H₆₄O₈
Molecular Weight: 672.93
MDL Number: MFCD00036737
Linear Formula: C₄₀H₆₄O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P8014-1MG	1 mg	$225.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

color	white
form	solid
InChI	1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
InChI key	DGOSGFYDFDYMCW-OEFRVDPMSA-N
Quality Level	100
SMILES string	CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC
solubility	DMSO: soluble
	ethanol: soluble
	methanol: soluble
storage temp.	−20°C

Application:	4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist: • to study its effects on Madin-Darby canine kidney (MDCK) cells • to study its effects on Ca²⁺ influx in mice fallopian tubal cells • to study its effects on hind paw swelling in mice
Biochem/physiol Actions:	4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.
Disclaimer:	Photosensitive
Packaging:	1, 5 mg in ampule
Preparation Note:	Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Symbol	GHS05,GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H314 - H317 - H334 - H351
Precautionary statements	P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	T+
Risk Statements	26/27/28-40-43
Safety Statements	36/37/39-45
RIDADR	UN 2811 6.1 / PGI
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352211

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