Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit
SIGMA/P8122 - affinity isolated antibody, lyophilized powder
Synonym: Anti-BIR1; Anti-GIRK-2; Anti-GIRK2; Anti-KATP-2; Anti-KATP2; Anti-KCNJ7; Anti-KIR3.2; Anti-KPLBS; Anti-hiGIRK2
MDL Number: MFCD07370454
Product Type: Chemical
Immunohistochemistry Anti-Kir3.2 (GIRK2): Cat. No. P8122: Immunohistochemical staining of perfusion-fixed frozen Mouse substantia nigra pars compacta sections using Anti-Kir3.2 (GIRK2) antibody, (1:400). GIRK2 staining (red) appears in cells and processes along the pars compacta of the Mouse substantia nigra (horizontal arrows) and in the pars reticulata (vertical arrows). Cell nuclei are stained with DAPI (blue).
Immunoblotting Anti-Kir3.2 (GIRK2): Cat. No. P8122: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Kir3.2 (GIRK2) antibody, (1:200). 2. Anti-Kir3.2 (GIRK2) antibody, preincubated with the control antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:200 using rat brain membranes |
| UniProt accession no. | P48550  |
| Application: | Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit has been used in: • immunoblotting • immunofluorescence • immunocytochemistry |
| Biochem/physiol Actions: | Anti-Potassium Channel KIR3.2 (GIRK2) recognizesKIR3.2 (GIRK2). |
| Biochem/physiol Actions: | G protein-activated inward rectifier potassium channel 2,(GIRK2) plays a key role in γ-aminobutyric acid-ergic (GABAergic), dopaminergic, cholinergic, and glutamatergic synapses. It also regulates neuronal excitability. GIRK2 through G protein-coupled receptor stimulation modulates neuronal circuit activity and heart rate in cardiac cells. Deletion of the GIRK2 gene in mice may lead to an anxiety-like phenotype and a depression-resistant behavior. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | G protein-activated inward rectifier potassium channel 2 (GIRK2) is localized on the plasma membrane. It is expressed majorly in the brain and to some extent in the pancreas. The GIRK2 gene is mapped to human chromosome 21q22.13. Structurally, GIRK2 exists as a tetramer and comprises a transmembrane domain and a cytoplasmic domain. |
| Immunogen: | GST fusion protein with sequence corresponding to residues 374-414 of mouse KIR3.2 (GIRK2). Sequence homology is 40/41, 39/41, and 37/41 residues identical in rat, golden hamster, and human, respectively. |
| Physical form: | Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |