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Protoporphyrin IX

SIGMA/P8293 - ≥95%

Synonym: 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid; Kammerer’s porphyrin; Ooporphyrin

CAS Number: 553-12-8
Empirical Formula (Hill Notation): C34H34N4O4
Molecular Weight: 562.66
EC Number: 209-033-7
MDL Number: MFCD00151109
Linear Formula: C34H34N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P8293-1G 1 g
 $144.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8293-1G

 

assay ≥95%
biological source Porcine
fluorescence λex 402 nm; λem 625 nm (bound to HRP)
  λex 409 nm; λem 633 nm
form powder
InChI 1S/C34H34N4O4/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25/h7-8,13-16,35,38H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42)/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-
InChI key KSFOVUSSGSKXFI-UJJXFSCMSA-N
Quality Level 100 
SMILES string Cc1c(CCC(O)=O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
solubility DMF: methanol (1:1): soluble-10 mg/mL, dark red-brown
storage temp. 2-8°C
Application: Activates soluble guanylyl cyclase.
Application: Protoporphyrin IX has been used:
• as a standard in protoporphyrin assays
• in fluorescence spectra analysis
• to treat cells in cell culture to study heme-mediated ferroportin 1 transcription
Biochem/physiol Actions: Protoporphyrin IX penetrates human erythrocytes and aids the release of oxygen from them. It forms complexes with myoglobin and hemoglobin. It is a photosensitizer used in the photodynamic therapy of cancer.
Biochem/physiol Actions: Protoporphyrin IX levels are elevated in tumor cells due to metabolism anomalies compared to normal cells.
General description: Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.
General description: Protoporphyrin IX imparts red color to heme and is the major porphyrin in blood. It is synthesized from protoporphyrinogen IX in the presence of protoporphyrinogen IX oxidase.
Packaging: 1 g in glass bottle
Purity ≥95%
Storage Temp. 2-8°C
UNSPSC 41106305

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