Phenylbutazone
SIGMA/P8386
Synonym: 4-
CAS Number: 50-33-9
Empirical Formula (Hill Notation): C19H20N2O2
Molecular Weight: 308.37
EC Number: 200-029-0
MDL Number: MFCD00005500
Linear Formula: C19H20N2O2
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8386-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8386-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8386-500G
| assay | ≥98% (HPLC) |
| biological source | synthetic (organic) |
| form | powder |
| InChI | 1S/C19H20N2O2/c1-2-3-14-1 |
| InChI key | VYMDGNCVAMGZFE-UHFFFAOYSA |
| mp | 106-108 °C (lit.) |
| Quality Level | 200  |
| SMILES string | CCCCC1C(=O)N(N(C1=O)c2ccc |
| solubility | ethanol: 50 mg/mL, clear, colorless to light yellow |
| Application: | Phenylbutazone has been used: • as a hepatotoxin in transgenic zebrafish line (LiPan) hepatotoxin assay • as a standard in high-performance liquid chromatography-ultraviole • as an anti-inflammatory compound in hen′s egg chorioallantoic membrane test (HET-CAM assay) |
| Biochem/physiol Actions: | Phenylbutazone is a hepatotoxin and binds to plasma proteins. It is used to treat inflammation in horse. Phenylbutazone has potential to treat ankylosing spondylitis. It has therapeutic potential to treat myotonic dystrophy type 1 (DM1) by inducing muscle blind-like protein 1 (MBNL1) expression. It also favors the expression of muscle chloride channel in skeletal muscles. |
| General description: | Non-steroidal anti-inflammatory compound; inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase. |
| Packaging: | 25, 100, 500 g in poly bottle |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 - H312 + H332 - H315 - H319 - H335 |
| Precautionary statements | P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 106-108 °C (lit.) |
| UNSPSC | 12352200 |