Psoralen
SIGMA/P8399 - ≥99% (HPLC)
Synonym: 6,7-Furanocoumarin; 7H-
CAS Number: 66-97-7
Empirical Formula (Hill Notation): C11H6O3
Molecular Weight: 186.16
EC Number: 200-639-7
MDL Number: MFCD00010520
Linear Formula: C11H6O3
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8399-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8399-10MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P8399-25MG
| assay | ≥99% (HPLC) |
| fluorescence | λex 335 nm; λem 460 nm (pH 7.0) |
| form | powder |
| InChI | 1S/C11H6O3/c12-11-2-1-7-5 |
| InChI key | ZCCUUQDIBDJBTK-UHFFFAOYSA |
| Quality Level | 200  |
| SMILES string | O=C1Oc2cc3occc3cc2C=C1 |
| storage temp. | 2-8°C |
| Application: | Photochemical reagent for the investigation of nucleic acid structure and function. |
| Application: | Psoralen has been used: • as a crosslinker for dsRNA for in- situ hybridization studies • in testing melanin dispersal effects in fish scale melanophores • to test its stimulatory effects in osteoblast a cell proliferation assay • as a reference standard in high-performance liquid chromatography (HPLC) |
| Biochem/physiol Actions: | Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis |
| Features and Benefits: | This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: | 10, 25, 100 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 - H317 |
| Precautionary statements | P280 - P301 + P312 + P330 - P302 + P352 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |