Protopine hydrochloride

SIGMA/P8489 - ≥98%, solid

CAS Number: 6164-47-2
Empirical Formula (Hill Notation): C₂₀H₁₉NO₅·HCl
Molecular Weight: 389.83
EC Number: 228-196-5
MDL Number: MFCD00236406
Linear Formula: C₂₀H₁₉NO₅·HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P8489-5MG	5 mg	$501.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
form	solid
InChI	1S/C20H19NO5.ClH/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17;/h2-3,7-8H,4-6,9-11H2,1H3;1H
InChI key	NWNVDSJZGYDVQW-UHFFFAOYSA-N
Quality Level	100
SMILES string	Cl.CN1CCc2cc3OCOc3cc2C(=O)Cc4ccc5OCOc5c4C1
storage temp.	2-8°C

Application:	Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.
Biochem/physiol Actions:	Protopine hydrochloride is a Ca²⁺ channel blocker and antiplatelet agent.
Biochem/physiol Actions:	Protopine possesses anti-parasitic, antimicrobial and anti-inflammatory property. It mediates mitotic arrest by favoring tubulin polymerization. Protopine elicits anti-invasive effects in breast cancer tumor progression.. It also provides protection against oxidative stress-induced cell death.
Disclaimer:	Protect from light.
General description:	Protopine is a celandine alkaloid and a bioactive compound associated with the plant families including fumariaceae, berberidaceae and papaveraceae. It is metabolized by demethylenation in the presence of the cytochrome enzymes cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).

Hazard Codes	T
Risk Statements	25
Safety Statements	36/37/39-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98%
Storage Temp.	2-8°C
UNSPSC	51111800

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