Phosphoinositide 3-kinase p110γ human
SIGMA/P8615 - ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution
Synonym: PI3K p110γ human; Phosphatidylinositol 3-kinase p110γ human
MDL Number: MFCD03457993
Product Type: Chemical
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| assay | ≥95% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected insect cells |
| shipped in | dry ice |
| specific activity | ~4.5 units/mg protein |
| storage temp. | −70°C |
| UniProt accession no. | P48736  |
| Biochem/physiol Actions: | Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder. |
| Biochem/physiol Actions: | PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression. |
| General description: | Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5 |
| Other Notes: | 1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate. |
| Physical form: | Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-PAGE) |
| activity | specific activity: ~4.5 units/mg protein |
| Storage Temp. | −70°C |
| UNSPSC | 12352207 |