5-Pregnen-3β-ol-20-one

SIGMA/P9129 - ≥98%

Synonym: 3β-Hydroxy-5-pregnen-20-one; Pregnenolone

CAS Number: 145-13-1
Empirical Formula (Hill Notation): C₂₁H₃₂O₂
Molecular Weight: 316.48
EC Number: 205-647-4
MDL Number: MFCD00003628
Linear Formula: C₂₁H₃₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P9129-1G	1 g	$60.40 1/EA	Add To Favorites
45-P9129-100G	100 g	$538.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: P9129-25G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98%
biological source	synthetic (organic)
form	powder
functional group	ketone
InChI	1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1
InChI key	ORNBQBCIOKFOEO-QGVNFLHTSA-N
Quality Level	200
shipped in	ambient
SMILES string	[H][C@@]12CC=C3C[C@@H](O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
solubility	ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow
storage temp.	room temp

Application:	5-Pregnen-3β-ol-20-one is suitable for use: • as a substrate for 3β-HSD at a concentration of 1 μg/mL to study the time-dependent effect of reduced oxygen tension on 3β-hydroxysteroid dehydrogenase (3β-HSD) activity • as a progestin precursor to study the effects of splenic macrophages on progestin secretion of luteal cells • in the testicular interstitial cell culture medium at a concentration of 15mg/mL
Biochem/physiol Actions:	One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.
Biochem/physiol Actions:	Testosterone production in rats occurs in Leydig cells of the testis via the Δ⁴ pathway. Cholesterol is first converted to pregnenolone, then to progesterone, and finally to testosterone. Pregnenolone is the key neurosteroid synthesized in steroidogenic glands. It is also present as a sulfate ester that serves as an antagonist of GABAergic neurons by interacting with γ-aminobutyric acid (GABA) receptor.
Packaging:	1, 5, 25, 100 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
Storage Temp.	room temp
UNSPSC	12352211

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