Plasminogen from bovine plasma
SIGMA/P9156 - lyophilized powder, ≥2.0 units/mg protein
Synonym: Profibrinolysin
CAS Number: 9001-91-6
EC Number: 232-641-9
MDL Number: MFCD00131922
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P9156-100UN
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P9156-10UN
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P9156-25UN
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P9156-5UN
| application(s) | histology |
| biological source | bovine plasma |
| concentration | 2-7% protein (biuret) |
| form | lyophilized powder |
| specific activity | ≥2.0 units/mg protein |
| storage temp. | 2-8°C |
| suitability | not suitable for streptokinase determination by clot formation procedure |
| UniProt accession no. | P00747   |
| P06868 |
| Biochem/physiol Actions: | Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β). |
| Biochem/physiol Actions: | The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling. |
| Other Notes: | ε-Aminocaproic acid free |
| Other Notes: | One unit will produce 1.0 μmole of p-nitroanilide from D-Val-Leu-Lys 4-nitroanilide at pH 7.5 at 37°C. |
| Physical form: | Lyophilized powder containing NaCl, EDTA, lysine, and Tris buffer salts |
| Preparation Note: | Solutions should be stored in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥2.0 units/mg protein |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352202 |