Polymyxin Acylase from Pseudomonas sp.
SIGMA/P9208 - ≥0.1 units/mg solid
Synonym: Peptide N-fatty acylase
CAS Number: 111174-43-7
MDL Number: MFCD00286307
Product Type: Chemical
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| biological source | bacterial (Pseudomonas spp.) |
| form | solid |
| Quality Level | 200  |
| relevant disease(s) | cancer |
| specific activity | ≥0.1 units/mg solid |
| storage temp. | −20°C |
| Analysis Note: | Crude actone powder; |
| Application: | Polymyxin acylase, from Pseudomonas sp., is a N-myristoyl cleaving enzyme that has been used to determine the N-myristoyl peptide sequence and may be useful in cancer research since it has antitumor activity against murine and human tumor cells . |
| Biochem/physiol Actions: | Polymyxin acylase, from Pseudomonas sp. deacylates polymyxin group antibiotics and long-chain fatty acyl groups of proteins. Polymyxin acylase has an affinity for long-chain fatty acyl proteins in human carcinoma cells . |
| Other Notes: | One unit will hydrolyze 1 μmole of N-octanoyl-5-aminovaleric acid per min at pH 8.0 at 37°C. |
| Hazard Codes | Xi |
| Risk Statements | 37 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥0.1 units/mg solid |
| Storage Temp. | −20°C |
| UNSPSC | 12352204 |