Pro-Phe-Arg-7-amido-4-methylcoumarin

SIGMA/P9273 - ≥95%

Synonym: PFR-Nmec

CAS Number: 65147-21-9 (free base)
Empirical Formula (Hill Notation): C₃₀H₃₇N₇O₅ · C₂H₄O₂
Molecular Weight: 635.71
Linear Formula: C₃₀H₃₇N₇O₅ · C₂H₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P9273-25MG	25 mg	$1140.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
composition	Peptide content, ≥65%
form	powder
InChI	1S/C30H37N7O5.ClH/c1-18-15-26(38)42-25-17-20(11-12-21(18)25)35-28(40)23(10-6-14-34-30(31)32)36-29(41)24(16-19-7-3-2-4-8-19)37-27(39)22-9-5-13-33-22;/h2-4,7-8,11-12,15,17,22-24,33H,5-6,9-10,13-14,16H2,1H3,(H,35,40)(H,36,41)(H,37,39)(H4,31,32,34);1H
InChI key	QYFPUTDFLKFOBA-UHFFFAOYSA-N
Quality Level	200
SMILES string	NC(NCCC[C@@H](C(NC1=CC=C(C(C)=CC(O2)=O)C2=C1)=O)NC([C@H](CC3=CC=CC=C3)NC(C4NCCC4)=O)=O)=N.CC([O-])=O
solubility	methanol: 50 mg/mL, clear, colorless to faintly yellow
storage temp.	−20°C

Application:	Pro-Phe-Arg-7-amido-4-methylcoumarin has been used as fluorogenic substrate: • in kinetic experiments to measure the enzymatic activity of factor XII • to measure the activity of generated plasma kallikrein using Spectramax plate reader • to determine the cathepsin A (CatA) inhibitor selectivity against various proteases using Tecan Safire 2 plate reader
General description:	A fluorogenic substrate for pancreatic and urinary kallikreins.
Packaging:	25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352204

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