Paromomycin sulfate salt

SIGMA/P9297 - ≥98% (TLC)

Synonym: Aminosidine sulfate

CAS Number: 1263-89-4
Empirical Formula (Hill Notation): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
Molecular Weight: 615.63 (free base basis)
Linear Formula: C₂₃H₄₅N₅O₁₄ · xH₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-P9297-1G	1 g	$114.00 1/EA		Add To Favorites
45-P9297-5G	5 g	$287.00 1/EA		Add To Favorites
45-P9297-25G	25 g	$1070.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	parasites
assay	≥98% (TLC)
form	powder
InChI	1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
InChI key	OYJABWUHUYVDMJ-UDXJMMFXSA-N
mode of action	protein synthesis \| interferes
Quality Level	200
SMILES string	O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

Application:	Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth. It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.
Biochem/physiol Actions:	Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth. Mode of Action: Inhibits initiation and elongation during protein synthesis.
Biochem/physiol Actions:	Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	1g,5g,25g

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
UNSPSC	51281663

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