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Poly-L-histidine

SIGMA/P9386 - mol wt 5,000-25,000

Synonym: L-Histidine homopolymer

CAS Number: 26062-48-6
MDL Number: MFCD00166382
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P9386-10MG 10 mg
 $177.00
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45-P9386-50MG 50 mg
 $492.00
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45-P9386-100MG 100 mg
 $910.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: P9386-100MG

 

application(s) cell analysis
color white to light yellow
form powder or solid
InChI 1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key HNDVDQJCIGZPNO-YFKPBYRVSA-N
mol wt 5,000-25,000
Quality Level 200 
SMILES string [N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]
storage temp. −20°C
Analysis Note: Molecular weight by MALLS.
Application: Poly-L-histidine has been used:
• as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
• as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
• in screening its anti-prion activity in cell based and in vivo anti-prion assay
Biochem/physiol Actions: Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.
General description: Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.
Other Notes: For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource .
Packaging: 10, 50, 100 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352209

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