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Phleomycin from Streptomyces verticillus

SIGMA/P9564 - powder

Synonym: FT-0697305

CAS Number: 11006-33-0
MDL Number: MFCD00131846
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P9564-5MG 5 mg
 $122.00
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45-P9564-25MG 25 mg
 $405.00
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45-P9564-100MG 100 mg
 $1350.00
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antibiotic activity spectrum fungi
color blue
form powder
InChI 1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1
InChI key QRBLKGHRWFGINE-UGWAGOLRSA-N
mode of action DNA synthesis | interferes
Quality Level 200 
shelf life 2 yr
storage temp. 2-8°C
Application: Phleomycin from Streptomyces verticillus has been used as an antibiotic in the screening of transformants of Trypanosoma brucei. It has also been used as an antibiotic in the maintenance of Escherichia coli.
Biochem/physiol Actions: Phleomycin can bind and intercalate with the DNA that leads to DNA strand breaks. It acts as an inhibitor of DNA replication.
Features and Benefits: This compound is a featured product for Apoptosis research. Click here  to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Phleomycin is a glycopeptide antibiotic and is a member of the bleomycin family.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P264 - P270 - P301 + P312 - P501
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 12352200

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