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Paroxetine hydrochloride hemihydrate

SIGMA/P9623 - ≥98% (HPLC), powder

Synonym: Paroxetine HCl; (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate

CAS Number: 110429-35-1
Empirical Formula (Hill Notation): C19H20FNO3 · HCl · .5 H2O
Molecular Weight: 374.83
MDL Number: MFCD03658863
Linear Formula: C19H20FNO3 · HCl · .5 H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P9623-10MG 10 mg
 $194.00
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45-P9623-50MG 50 mg
 $715.00
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assay ≥98% (HPLC)
color white
form powder
InChI 1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
InChI key QRQSGFFISBKLMZ-YHOFXEKLSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
storage condition desiccated
Application: Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro; as a CYP 2D6 inhibitor to study its effects on the in vitro production by human recombinant CYP 2D6 of the phenolic metabolites; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons
Biochem/physiol Actions: Paroxetine hydrochloride hemihydrate is one of the most potent and selective of the selective serotonin reuptake inhibitors (SSRI); antidepressant
Biochem/physiol Actions: Paroxetine is a phenylpiperidine derivative. It has the ability to cross placenta. Paroxetine is known to increase the risk of congenital cardiac malformations. It might be useful in hormone replacement therapy for treating vasomotor symptoms during menopause. It is known to ameliorate the effects of panic disorder, obsessive‐compulsive disorder and social phobia.
Biochem/physiol Actions: Selective serotonin reuptake inhibitor; antidepressant
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information: Sold with the permission of GlaxoSmithKline
Packaging: 10, 50 mg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

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