BIS-TRIS propane
SIGMA/PHG0005
Synonym: 1,3-
CAS Number: 64431-96-5
Empirical Formula (Hill Notation): C11H26N2O6
Molecular Weight: 282.33
EC Number: 264-899-3
MDL Number: MFCD00004689
Linear Formula: CH2[CH2NHC(CH2OH)3]2
Product Type: Chemical
Photo is meant to be representative of product you will receive if ordered. Additional information is printed on actual labels and package types are subject to change.
| biological source | synthetic |
| foreign activity | Cytotoxicity, DNase, NICKase, RNase, and Protease; tested |
| form | powder |
| impurities | Endotoxin, microbial, and trace metals; tested |
| InChI | 1S/C11H26N2O6/c14-4-10(5- |
| InChI key | HHKZCCWKTZRCCL-UHFFFAOYSA |
| mp | 164-165 °C (lit.) |
| pKa (25 °C) | (1) 6.8, (2) 9.0 |
| Quality Level | 400  |
| SMILES string | OCC(CO)(CO)NCCCNC(CO)(CO) |
| suitability | suitable for manufacturing use |
| technique(s) | cell culture | mammalian: suitable |
| useful pH range | 6.3-9.5 |
| Application: | Bis Tris Propane is a unique biological buffer also referred to as a “Universal” buffer, which means the buffer capacity covers a wide range. Bis Tris Propane has two pKas of 6.3 and 9.5, which expands the buffering range from 5.0-10.5-making this a versatile buffer for biological systems. Bis Tris Propane is considered to be non-toxic to culture cell lines and provides high-solution clarity. A review of DNA polymerase techniques lists bis tris propane as a suitable buffer for PCR methods as a universal buffer pH gradient is employed. |
| General description: | Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program. M-Clarity Program Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step. Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs. |
| Legal Information: | SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 10 kg in poly drum |
| Packaging: | 100 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 164-165 °C (lit.) |
| UNSPSC | 12161705 |