Guanidine hydrochloride
SIGMA/PHG0006
Synonym: Aminoformamidine hydrochloride; Aminomethanamidine hydrochloride; Guanidinium chloride
CAS Number: 50-01-1
Empirical Formula (Hill Notation): CH5N3 · HCl
Molecular Weight: 95.53
EC Number: 200-002-3
MDL Number: MFCD00013026
Linear Formula: NH2C(=NH)NH2 · HCl
Product Type: Chemical
| biological source | synthetic |
| density | 1.3 g/cm3 (lit.) |
| foreign activity | Dnase and RNase; tested |
| form | powder |
| impurities | Endotoxin, microbial, and trace metals; tested |
| InChI | 1S/CH5N3.ClH/c2-1(3)4;/h( |
| InChI key | PJJJBBJSCAKJQF-UHFFFAOYSA |
| mp | 180-185 °C (lit.) |
| pH | (25 °C, 4.6 - 6/573 g/L) |
| Quality Level | 400  |
| SMILES string | Cl[H].NC(N)=N |
| solubility | H2O: 6 M at 20 °C, clear, colorless |
| suitability | suitable for manufacturing use |
| Application: | Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. |
| General description: | Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program. M-Clarity Program Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs. |
| Legal Information: | SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany |
| Packaging: | 100 g in poly bottle |
| Packaging: | 5, 25, 50 kg in poly drum |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 + H332 - H315 - H319 |
| Precautionary statements | P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/38 |
| Safety Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 180-185 °C (lit.) |
| Density | 1.3 g/cm3 (lit.) |
| UNSPSC | 12352107 |