Rabbit anti-Mre11 Antibody, Affinity Purified
SIGMA/PLA0057 - Powered by Bethyl Laboratories, Inc.
Synonym: AT-like disease; ATLD; DNA recombination and repair protein; HNGS1; MRE11; MRE11 double strand break repair nuclease A; MRE11 homolog; MRE11 homolog 1; MRE11 homolog A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11 meiotic recombination 11-like protein A; MRE11B; double strand break repair nuclease A; endo/exonuclease Mre11; meiotic recombination (S. cerevisiae) 11 homolog A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A
Product Type: Product-on-demand
Immunohistochemistry Rabbit Anti-Mre11 Antibody, Affinity Purified: Cat. No. PLA0057: Detection of Human Mre11 by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma. Antibody: Affinity purified Rabbit Anti-Mre11 (Cat. No. PLA0057) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB
Western Blotting Rabbit Anti-Mre11 Antibody, Affinity Purified: Cat. No. PLA0057: Detection of Human Mre11 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 μg) from HeLa cells. Antibodies: Affinity purified Rabbit Anti-Mre11 Antibody PLA0057 used for WB at 0.1 μg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
| accession no. | NP_005582.1 |
| antibody form | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:1,000-1:5,000 |
| western blot: 1:1,000- 1:5,000 | |
| UniProt accession no. | P49959  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | The epitope recognized by PLA0057 maps to a region between residues 1 and 50 of human Meiotic Recombination 11 homolog A using the numbering given in entry NP_005582.1 (GeneID 4361). |
| Other Notes: | Mre11 is a component of the MRN complex and plays a role in telomere maintenance and double-strand break (DSB) repair. Mre11 associates with rad50 in the MRN complex. Mre11 possesses 3’– 5’ exonuclease activity that is involved in creating DNA termini in DSB suitable for priming DNA synthesis and ligation. |
| Physical form: | Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |