Rabbit anti-PARP1 Antibody, Affinity Purified
SIGMA/PLA0184 - Powered by Bethyl Laboratories, Inc.
Synonym: ADP-
Product Type: Product-on-demand
Western Blotting Rabbit Anti-PARP1 Antibody, Affinity Purified: Cat. No. PLA0184: Detection of Human PARP1 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 μg) from 293T cells. Antibody: Affinity purified Rabbit Anti-PARP1 Antibody PLA0184 used for WB at 0.04 μg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
| accession no. | NP_001609.1 |
| antibody form | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:2,000-1:10,000 |
| UniProt accession no. | P09874  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | The epitope recognized by PLA0184 maps to a region between residue 1 and 50 of human poly (ADP-ribose) polymerase family, member 1 using the numbering given in entry NP_001609.1 (GeneID 142). |
| Other Notes: | PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(+) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury. |
| Physical form: | Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |