Rabbit anti-ESCO2 Antibody, Affinity Purified
SIGMA/PLA0207 - Powered by Bethyl Laboratories, Inc.
Synonym: 2410004I17Rik; ECO1 homolog 2; EFO2; Establishment of cohesion 1 homolog 2; RBS; Roberts syndrome; establishment of cohesion 1 homolog 2 (S. cerevisiae)
Product Type: Product-on-demand
Western Blotting Rabbit Anti-ESCO2 Antibody, Affinity Purified: Cat. No. PLA0207: Detection of Human ESCO2 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 μg) from HeLa cells. Antibodies: Affinity purified Rabbit Anti-ESCO2 antibody Cat. No. PLA0207 used for WB at 0.1 μg/mL. Detection: Chemiluminescence with exposure time of 30 seconds.
Immunoprecipitation Rabbit Anti-ESCO2 Antibody, Affinity Purified: Cat. No. PLA0207: Detection of Human ESCO2 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified Rabbit Anti-ESCO2 antibody Cat. No. PLA0207 used for WB at 1 μg/mL and for IP at 3 μg/mg lysate. ESCO2 was also immunoprecipitated by Rabbit Anti-ESCO2 Antibody B, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure time of 30 seconds.
| accession no. | NP_001017420.1 |
| antibody form | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| technique(s) | immunoprecipitation (IP): 2-10 μg/mg |
| western blot: 1:2,000- 1:10,000 | |
| UniProt accession no. | Q56NI9  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Immunogen: | The epitope recognized by PLA0207 maps to a region between residue 200 and 250 of human establishment of cohesion 1 homolog 2 using the numbering given in entry NP_001017420.1 (GeneID 157570). |
| Other Notes: | ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure. |
| Physical form: | Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |