Anti-CASPASE-12 (ab1) antibody produced in rabbit
SIGMA/PRS2325 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Casp-12
MDL Number: MFCD03454856
Product Type: Chemical
Immunohistochemistry Anti-Caspase-12: Cat. No. PRS2325 Immunohistochemistry of Caspase-12 in human heart tissue with Caspase-12 antibody at 10 μg/mL.
Immunoblotting Anti-Caspase-12: Cat. No. PRS2325 Western blot analysis of caspase-12 in human (A) and mouse (B) spleen tissue lysates with caspase-12 antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 46 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | O08736  |
| Application: | Anti-CASPASE-12 (ab1) antibody produced in rabbit has been used in western blotting. |
| Biochem/physiol Actions: | Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Caspase 12 (CASP12), a member of the caspase family, is expressed in the Golgi complex. |
| Immunogen: | a peptide corresponding to amino acids 2-17 of murine caspase-12. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP2325 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |