Anti-IKAP antibody produced in rabbit
SIGMA/PRS2337 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-IKBKAP; Anti-IKK complex-associated protein; Anti-Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
MDL Number: MFCD04118553
Product Type: Chemical
Immunocytochemistry Anti-IKAP: Cat. No. PRS2337 Immunocytochemistry of IKAP in A-20 cells with IKAP antibody at 1 μg/mL.
Immunofluorescence Immunofluorescence of IKAP in A20 cells with IKAP antibody at 20 μg/mL.
Immunoblotting Anti-IKAP: Cat. No. PRS2337 Western blot analysis of IKAP in A-20 cell lysate with IKAP antibody at in (A) 0.5, and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 134-147 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: suitable |
| immunofluorescence: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | O95163  |
| Biochem/physiol Actions: | Mutations in IKAP cause familial dysautonomia. It helps to conserve the proliferation of neural precursor and blocks its unexpected differentiation into neurons. It plays an important role in cell motility and migration. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | IKAP (IKK-complex-associated protein) is considered as a subunit of the RNA Pol II elongator complex. It is also known as IKBKAP (Ikappakinase complex-associated protein or human elongator factor 1) and ELP1 (elongator protein-1). It has 37 exons and codes for 1332 amino acid IKAP protein, that is of ~150KD. It is present in most of the tissues. It is mapped to chromosome 9q31. |
| Immunogen: | a 16 amino acid peptide from near the carboxy-terminus of human IKAP. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP2337 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |