Anti-MTBP antibody produced in rabbit
SIGMA/PRS2447 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
Product Type: Chemical
Immunocytochemistry Anti-MTBP: Cat. No. PRS2447 Immunocytochemistry of MTBP in K562 cells with MTBP antibody at 5 μg/mL.
Immunofluorescence Immunofluorescence of MTBP in K562 cells with MTBP antibody at 20 μg/mL.
Immunoblotting Anti-MTBP: Cat. No. PRS2447 Western blot analysis of MTBP expression in K562 whole cell lysates with MTBP antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 104 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunocytochemistry: suitable |
| immunofluorescence: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q96DY7  |
| Biochem/physiol Actions: | The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases. |
| Immunogen: | a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP2447 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |