Anti-Caspase-12 (small) antibody produced in rabbit
SIGMA/PRS3197 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Caspase 12
MDL Number: MFCD03454855
Product Type: Chemical
Immunohistochemistry Anti-Caspase-12 (Small): Cat. No. PRS3197 Immunohistochemical staining of human liver tissue using Caspase-12 antibody (small) at 10 μg/mL.
Immunoblotting Anti-Caspase-12 (Small): Cat. No. PRS3197 Western blot analysis of caspase-12 in mouse (Lane A) and rat (Lane B) liver lysate with caspase-12 antibody (small) at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 46 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: suitable |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | O08736  |
| Biochem/physiol Actions: | Caspase-12 (CASP12) plays an important role in endoplasmic reticulum (ER)-related apoptosis. It moderates hepatocyte apoptosis prompted by carbon tetrachloride. Lack of caspase-12 (CASP12) increases cytokine responses. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Caspase-12 (CASP12) is an immunomodulatory factor, that is present in the cytoplasmic side of the ER (endoplasmic reticulum). It is upregulated highly in muscle, liver and kidney. |
| Immunogen: | a synthetic peptide corresponding to amino acids within the small cleavage product of murine caspase-12. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3197 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |