Anti-IRF7 (ab1) antibody produced in rabbit
SIGMA/PRS3941 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Interferon regulatory factor 7
MDL Number: MFCD02096777
Product Type: Chemical
Immunohistochemistry Anti-IRF7: Cat. No. PRS3941 Immunohistochemistry of ?IRF7 in mouse spleen tissue with IRF7 antibody at 5 μg/mL.
Immunofluorescence Immunofluorescence of IRF7 in Mouse Spleen cells with IRF7 antibody at 20 μg/mL.
Immunoblotting Anti-IRF7: Cat. No. PRS3941 Western blot analysis of IRF7 in 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q92985  |
| Application: | Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting. |
| Biochem/physiol Actions: | Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5. |
| Immunogen: | a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 . |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3941 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |