Anti-PDL-1 antibody produced in rabbit
SIGMA/PRS4059 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-B7-H1; Anti-CD274 molecule; Anti-Cardif; Anti-IPS-1; Anti-Programmed cell death 1 ligand-1
Product Type: Chemical
Immunohistochemistry Anti-PDL-1: Cat. No. PRS4059 Immunohistochemistry of PDL-1 in human heart tissue with PDL-1 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of PD-L1 in Human Heart cells with PD-L1 antibody at 20 μg/mL.
Immunoblotting Anti-PDL-1: Cat. No. PRS4059 Western blot analysis of PDL-1 in Raji cell lysate with PDL-1 antibody at (A) 0.5 and (B) 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 32 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | flow cytometry: suitable |
| immunofluorescence: suitable | |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q9NZQ7  |
| Biochem/physiol Actions: | PDL-1 (programmed cell death 1 ligand 1) helps to clear sudden HPV (human papilloma virus) infections. It prevents the multiplication and adherence of T-cell and production of cytokine. It also controls the activities of T-cells in peripheral tissues. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | PDL-1 (programmed cell death 1 ligand 1) is a cell surface protein, that is also known as B7-H1 (B7 homolog 1), coded by CD274 (cluster of differentiation 274) gene. It is located on chromosome 9p24.1. It is present on placental cells, vascular endothelial cells, liver cells, epithelial cells, mesenchymal stem cells, B cells, T cells, dendritic cells and macrophages. It is also expressed in various tumor types like melanoma, glioblastoma, cancers in the lung, kidney, head, neck, stomach, colon, pancreas, breast, cervix and ovary. |
| Immunogen: | 17 amino acid peptide from near the center of human PDL-1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP4059 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |