Anti-PD-1 (ab1) antibody produced in rabbit
SIGMA/PRS4065 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-CD279; Anti-PDCD1; Anti-Programmed cell death 1
Product Type: Chemical
Immunohistochemistry Anti-PD-1: Cat. No. PRS4065 Immunohistochemistry of PD-1 in human brain tissue with PD-1 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of PD-1 in Human Brain tissue with PD-1 antibody at 20 μg/mL.
Immunoblotting Anti-PD-1: Cat. No. PRS4065 Western blot analysis of PD-1 in THP-1 cell lysate with PD-1 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | predicted mol wt 32 kDa |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | Q15116  |
| Biochem/physiol Actions: | PD-1 (programmed death-1) gene is sensitive to systemic lupus erythematosus (SLE). Polymorphisms in PD-1 may participate in the growth of EOC (epithelial ovarian cancer). It acts as a negative regulator of T cells. It is also responsible for immune escape mediated by tumor cell. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | PD-1 (programmed death-1) is an immunosuppressive molecule, which is also known as PDCD1 (programmed cell death 1). It is located on chromosome 2q37.3. It is a member of immunoglobulin receptor superfamily. |
| Immunogen: | a 16 amino acid peptide from near the carboxy-terminus of human PD-1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP4065 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |