Anti-Nhe-1 (ab2) antibody produced in rabbit
SIGMA/PRS4379 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-Na+/H+ antiporter; Anti-SLC9A1; Anti-Sodium-hydrogen exchanger 1; Anti-Solute carrier family 9 (sodium/hydrogen exchanger), member 1; Anti-Solute carrier family 9 member 1
Product Type: Chemical
Immunohistochemistry Anti-Nhe-1: Cat. No. PRS4379 Immunohistochemical staining of human brain tissue using Nhe-1 antibody at 2.5 μg/mL.
Immunofluorescence Immunofluorescence of Nhe-1 in Human Brain cells with Nhe-1 antibody at 20 μg/mL.
Immunoblotting Anti-Nhe-1: Cat. No. PRS4379 Western blot analysis of Nhe-1 in MOLT4 cell lysate with in with Nhe-1 antibody at (A) 1 and (B) 2 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| immunohistochemistry: suitable | |
| indirect ELISA: suitable | |
| western blot: suitable | |
| UniProt accession no. | P19634  |
| Application: | Anti-Nhe-1 (ab2) antibody has been used in immunohistochemistry. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper) |
| Biochem/physiol Actions: | Na+/H+ exchanger 1 (NHE1) modulates intracellular pH by exchanging a proton for an extracellular sodium ion and affects cell growth, proliferation, migration and apoptosis. It plays a major role in cancers including breast cancer, hepatocellular carcinoma, colon cancer, pancreatic ductal adenocarcinoma, prostate cancer, cervical cancer and neuroblastoma. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | SLC9A1 (solute carrier family 9 member A1)/Na+/H+ exchanger 1 (NHE1), a plasma membrane transporter, is mapped to human chromosome 1p36. It belongs to the NHE family. NHE1 is abundantly expressed in all organisms. |
| Immunogen: | a 17 amino acid peptide near the center of the human Nhe-1. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP4379 . |
| Physical form: | Solution in phosphate buffered saline containing 0.02% sodium azide |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |