Bazedoxifene acetate
SIGMA/PZ0018 - ≥98% (HPLC)
Synonym: 1-
CAS Number: 198481-33-3
Empirical Formula (Hill Notation): C30H34N2O3 · C2H4O2
Molecular Weight: 530.65
Linear Formula: C30H34N2O3 · C2H4O2
Product Type: Chemical
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C30H34N2O3.C2H4O2/c1-2 |
| InChI key | OMZAMQFQZMUNTP-UHFFFAOYSA |
| Quality Level | 100  |
| shipped in | wet ice |
| SMILES string | [N+H]5(CCCCCC5)CCOc1ccc(c |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Bazedoxifene acetate has been used to study its efficacy in inhibiting the interleukin-6 (IL-6)/IL-6R/glycoprotein 130 pathway and its effects on medulloblastoma cells. |
| Biochem/physiol Actions: | Bazedoxifene is a third generation nonsteroidal selective estrogen receptor modulator (SERM), used clinically to treat postmenopausal osteoporosis. Bazedoxifene binds to estrogen receptor-α with IC50 = 26 nM, similar to that of raloxifene, but lower affinity than 17-β estradiol. Bazedoxifene did not stimulate proliferation of MCF-7 cells, instead inhibited 17β -estradiol-induced proliferation with IC50 = 0.19 nM, exhibiting a desirable profile of agonist/antagonist activity. |
| Biochem/physiol Actions: | Bazedoxifene is a third generation nonsteroidal selective estrogen receptor modulator (SERM). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |