Synonym: 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one camsylate
CAS Number: 1859053-21-6
Empirical Formula (Hill Notation): C19H18FN3O · C10H16O4S
Molecular Weight: 555.66
Linear Formula: C19H18FN3O · C10H16O4S
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
pale yellow |
| form |
powder |
| InChI |
1S/C19H18FN3O.C10H16O4S/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);7H,3-6H2,1-2H3,(H,12,13,14)/t;7-,10-/m.1/s1 |
| InChI key |
INBJJAFXHQQSRW-STOWLHSFSA-N |
| shipped in |
dry ice |
| SMILES string |
FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O |
| solubility |
DMSO: 2 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
PARP Inhibitor; anticancer agent |
| Biochem/physiol Actions: |
Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer. |
| Symbol |
 GHS08 |
| Signal word |
Warning |
| Hazard statements |
H361 |
| Precautionary statements |
P280 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352202 |
