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PD-166866

SIGMA/PZ0114 - ≥98% (HPLC)

Synonym: 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea

CAS Number: 192705-79-6
Empirical Formula (Hill Notation): C20H24N6O3
Molecular Weight: 396.44
MDL Number: MFCD12922514
Linear Formula: C20H24N6O3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0114-5MG 5 mg
 $144.00
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45-PZ0114-25MG 25 mg
 $803.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white to light tan
InChI 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
InChI key NHJSWORVNIOXIT-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1cc(OC)cc(c1)-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
Biochem/physiol Actions: PD-166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the FGFR  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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