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PF-4708671

SIGMA/PZ0143 - ≥98% (HPLC)

Synonym: 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

CAS Number: 1255517-76-0
Empirical Formula (Hill Notation): C19H21F3N6
Molecular Weight: 390.41
MDL Number: MFCD18086922
Linear Formula: C19H21F3N6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0143-5MG 5 mg
 $148.00
1/EA		 Add To Favorites
45-PZ0143-25MG 25 mg
 $601.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white
form powder
InChI 1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChI key FBLPQCAQRNSVHB-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2
solubility DMSO: ≥20 mg/mL
storage temp. room temp
Biochem/physiol Actions: PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor.
Biochem/physiol Actions: PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.
Features and Benefits: This compound is featured on the PKB/Akt  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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