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UK-356618

SIGMA/PZ0152 - ≥98% (HPLC)

Synonym: (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide; UK-356,618

CAS Number: 230961-08-7
Empirical Formula (Hill Notation): C34H43N3O4
Molecular Weight: 557.72
MDL Number: MFCD19443865
Linear Formula: C34H43N3O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0152-25MG 25 mg
 $471.00
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assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C34H43N3O4/c1-23-21-25(19-20-29(23)27-16-10-7-11-17-27)13-12-18-28(22-30(38)37-41)32(39)36-31(34(3,4)5)33(40)35-24(2)26-14-8-6-9-15-26/h6-11,14-17,19-21,24,28,31,41H,12-13,18,22H2,1-5H3,(H,35,40)(H,36,39)(H,37,38)/t24-,28-,31-/m1/s1
InChI key JJHRUUKMPWUYIB-HVOSOHGQSA-N
optical activity [α]/D >+25.0°, c = 0.5 in methanol
Quality Level 100 
SMILES string C[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCc1ccc(c(C)c1)-c2ccccc2)CC(=O)NO)C(C)(C)C)c3ccccc3
solubility DMSO: ≥25 mg/mL
storage temp. 2-8°C
Application: UK-356618 has been used as a specific matrix metalloproteinase 3 (MMP3) inhibitor to study its effect on amitriptyline-induced glial cell line-derived neurotrophic factor (GDNF) mRNA expression and to confirm its influence on amitriptyline-induced zymographic MMP-9 activation in rat C6 astroglial cells.
Biochem/physiol Actions: Selective inhibitor of matrix metalloproteinase MMP3.
Biochem/physiol Actions: UK 356618 has the potential to inhibit interleukin (IL)-6-induced cell migration in NCI H446 small cell lung cancer cells in vitro.
Biochem/physiol Actions: UK-356,618 is a potent, selective inhibitor of Matrix metalloproteinase MMP3 (stromelysin-1). MMP-3 IC50 = 5.9 nM, selectivity is 140-fold vs MMP-1, -2, -9, and -14.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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