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PF 3845 hydrate

SIGMA/PZ0158 - ≥98% (HPLC)

Synonym: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate

CAS Number: 1196109-52-0
Empirical Formula (Hill Notation): C24H23F3N4O2 · xH2O
Molecular Weight: 456.46 (anhydrous basis)
MDL Number: MFCD21365072
Linear Formula: C24H23F3N4O2 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0158-5MG 5 mg
 $145.00
1/EA		 Add To Favorites
45-PZ0158-25MG 25 mg
 $550.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to tan
form powder
InChI 1S/C24H23F3N4O2.H2O/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20;/h1-7,10,14-17H,8-9,11-13H2,(H,30,32);1H2
InChI key CVQMBUCCSAKASE-UHFFFAOYSA-N
Quality Level 100 
SMILES string O.FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc4cccnc4)c2)nc1
solubility DMSO: ≥45 mg/mL
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: PF 3845 hydrate is a potent, irreversible FAAH inhibitor
Biochem/physiol Actions: PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..
Packaging: 5, 25 mg in glass bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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