Synonym: (2R,4S)-4-((3,5-Bis-trifluoromethylbenzyl)methoxycarbonylamino)-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester; CP-529,414; CP-529414
CAS Number: 262352-17-0
Empirical Formula (Hill Notation): C26H25F9N2O4
Molecular Weight: 600.47
MDL Number: MFCD09260777
Linear Formula: C26H25F9N2O4
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
powder |
| InChI |
1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1 |
| InChI key |
CMSGWTNRGKRWGS-NQIIRXRSSA-N |
| optical activity |
[α]/D >-70° |
| Quality Level |
100  |
| SMILES string |
CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c3cc(ccc13)C(F)(F)F |
| solubility |
DMSO: >5 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Torcetrapib has been used as a reference standard in the medium chain-lipid based formulations. |
| Biochem/physiol Actions: |
Cholesteryl ester transfer protein (CETP) inhibitor. |
| Biochem/physiol Actions: |
Torcetrapib is a Cholesteryl ester transfer protein (CETP) inhibitor. CETP normally transfers cholesterol from HDL cholesterol to very low density or low density lipoproteins (VLDL or LDL). Inhibition of this process results in higher HDL levels (the "good" cholesterol-containing particle) and reduces LDL levels (the "bad" cholesterol). Unfortunately clinical trials were stopped because of excessive all cause mortality. Reasons are still being investigated, but may be related to some off target effects such as an increase in aldosterone secretion not found in some other CETP inhibitors. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
