Synonym: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride
CAS Number: 142715-48-8
Empirical Formula (Hill Notation): C31H36N4O6 · HCl
Molecular Weight: 597.10
MDL Number: MFCD00911858
Linear Formula: C31H36N4O6 · HCl
Product Type: Chemical
| assay |
>98% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H |
| InChI key |
WWCHXVYTCMPAMV-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC |
| solubility |
DMSO: >5 mg/mL |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Biochem/physiol Actions: |
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. |
| Biochem/physiol Actions: |
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM). |
| Features and Benefits: |
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
>98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12161501 |
